Journal: Alzheimer's & Dementia : Diagnosis, Assessment & Disease Monitoring
Article Title: Cross-sectional and longitudinal atrophy is preferentially associated with tau rather than amyloid β positron emission tomography pathology
doi: 10.1016/j.dadm.2018.02.003
Figure Lengend Snippet: The relationship between global AD pathology and gray matter. Three GLMs were implemented to estimate vertex-wise relationships between (A) global tau PET summary measure, (B) Aβ mean cortical SUVR, or (C) global tau controlling for Aβ, and left-hemisphere cross-sectional cortical thickness. Spatiotemporal LMEs models were used to investigate relationships between (D) global tau and time from initial MRI, (E) global Aβ and time, or (F) global tau and time controlling for Aβ and time, and antecedent longitudinal change in cortical thickness. All models controlled for the main effects of gender, current age, and scan resolution. Cross-sectional models used the Qdec multiple comparisons correction (FDR) procedure at P < .025 level to approximate comparisons in both hemispheres. Longitudinal models used the LME FDR2 comparisons correction in MATLAB and accounted for comparisons in both hemispheres. Values depicted from each model are thresholded at the level of significance identified by their respective FDR procedures. Abbreviations: Aβ, amyloid β; AD, Alzheimer's disease; FDR, false discovery rate; GLM, general linear model; LMEs, linear mixed-effects; MRI, magnetic resonance imaging; PET, positron emission tomography; SUVR, standardized uptake value ratio.
Article Snippet: The first set of analyses examined relationships of pathology with antecedent longitudinal change in cortical thickness at the cortical surface level using spatiotemporal linear mixed-effects (LMEs) models , implemented in MATLAB.
Techniques: Magnetic Resonance Imaging, Positron Emission Tomography
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